Faure Céline, Mnie-Filali Ouissame, Scarna Hélène, Debonnel Guy, Haddjeri Nasser
Laboratory of Neuropharmacology and Neurochemistry, Faculty of Pharmacy, University of Claude Bernard Lyon I, France.
Neurosci Lett. 2006 Aug 14;404(1-2):122-6. doi: 10.1016/j.neulet.2006.05.023. Epub 2006 Jun 8.
The physiological function of 5-HT(7) receptors is not yet fully determined. This study was designed to characterize the involvement of 5-HT(7) receptor in rat body temperature regulation and in adrenocorticotropic hormone (ACTH) and corticosterone secretion. In the first part of our study, acute administration of SB-269970 (0.1-1 mg/kg, i.p.), a potent and selective 5-HT(7) receptors antagonist, dose-dependently prevented 5-HT(1A/7) receptor agonist 8-OH-DPAT (0.1 mg/kg, s.c.)-induced hypothermia and when the 5-HT(1A) receptor antagonist WAY-100,635 was co-injected with SB-269970, a reduction of the latter hypothermia was obtained in an additive manner. In contrast, 1 mg/kg (i.p.) of SB-269970 failed to prevent 8-OH-DPAT (0.5 mg/kg, s.c.)-induced increase of ACTH and corticosterone plasma levels. In conclusion, the present results unveil an additive effect of both 5-HT(1A) and 5-HT(7) receptors in core body temperature regulation.
5-羟色胺（7）受体的生理功能尚未完全明确。本研究旨在明确5-羟色胺（7）受体在大鼠体温调节以及促肾上腺皮质激素（ACTH）和皮质酮分泌过程中的作用。在我们研究的第一部分中，强效选择性5-羟色胺（7）受体拮抗剂SB-269970（0.1 - 1毫克/千克，腹腔注射）的急性给药，剂量依赖性地阻止了5-羟色胺（1A/7）受体激动剂8-羟基二丙胺基四氢萘（8-OH-DPAT，0.1毫克/千克，皮下注射）诱导的体温过低，并且当5-羟色胺（1A）受体拮抗剂WAY-100,635与SB-269970共同注射时，后者导致的体温过低以相加的方式减轻。相比之下，1毫克/千克（腹腔注射）的SB-269970未能阻止8-OH-DPAT（0.5毫克/千克，皮下注射）诱导的ACTH和皮质酮血浆水平升高。总之，目前的结果揭示了5-羟色胺（1A）和5-羟色胺（7）受体在核心体温调节中的相加作用。
