O'Loughlin V, Dickie A C, Ebmeier K P
Department of Mental Health, University of Aberdeen, Foresterhill.
J Neurol Neurosurg Psychiatry. 1991 Apr;54(4):363-4. doi: 10.1136/jnnp.54.4.363.
Thirty acute psychiatric patients were examined prospectively at the beginning of neuroleptic treatment for acute psychotic symptoms and on average 16 days later. Two alternative hypotheses were examined: 1) neuroleptic treatment affects the levels of serum iron and transferrin; 2) acute akathisia developing during the initial few weeks of treatment is associated with low levels of serum iron and transferrin, either initially or at follow up or both. Serum iron levels did not change on repeat measurement, while there was a small, but significant decrease of serum transferrin. There was a significantly greater decrease in iron and transferrin levels in patients with akathisia on follow up compared with non-akathisics. In addition, akathisia ratings were highly correlated with serum transferrin levels on follow up.
30例急性精神病患者在开始使用抗精神病药物治疗急性精神病症状时以及平均16天后进行了前瞻性检查。检验了两种备择假设：1）抗精神病药物治疗会影响血清铁和转铁蛋白水平；2）治疗最初几周出现的急性静坐不能与血清铁和转铁蛋白水平低有关，无论是在初始阶段、随访时还是两者皆有。重复测量时血清铁水平未发生变化，而血清转铁蛋白有小幅但显著的下降。与无静坐不能的患者相比，有静坐不能的患者在随访时铁和转铁蛋白水平的下降明显更大。此外，随访时静坐不能评分与血清转铁蛋白水平高度相关。
