外周苯二氮䓬类药物增强腺苷对大鼠输精管的作用。

Peripheral benzodiazepines potentiate the effect of adenosine in rat vas deferens.

作者信息

Escubedo E, Camarasa J, Pallas M, Adzet T

机构信息

Laboratory of Pharmacology and Pharmacognosy, Faculty of Pharmacy, University of Barcelona, Spain.

出版信息

J Pharm Pharmacol. 1991 Jan;43(1):49-50. doi: 10.1111/j.2042-7158.1991.tb05448.x.

DOI:10.1111/j.2042-7158.1991.tb05448.x

PMID:1676060

Abstract

Ro 5-4864, diazepam, clonazepam and PK 11195 inhibit the responses of rat was deferens following electrical stimulation in the rank order Ro 5-4864 greater than PK 11195 = diazepam greater than clonazepam. The adenosine-inhibited electrically-induced response was potentiated by Ro 5-4864 or diazepam, but not by clonazepam or PK 11195. This potentiation is due to an inhibition of the adenosine uptake system.

摘要

Ro 5-4864、地西泮、氯硝西泮和PK 11195抑制大鼠输精管在电刺激后的反应，其抑制顺序为Ro 5-4864＞PK 11195 = 地西泮＞氯硝西泮。腺苷抑制的电诱发反应可被Ro 5-4864或地西泮增强，但不能被氯硝西泮或PK 11195增强。这种增强是由于腺苷摄取系统受到抑制。