苯二氮䓬类药物Ro 5-4864可增加冠状动脉血流量。
Benzodiazepine Ro 5-4864 increases coronary flow.
作者信息
Grupp I L, French J F, Matlib M A
机构信息
Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, OH 45267-0575.
出版信息
Eur J Pharmacol. 1987 Nov 3;143(1):143-7. doi: 10.1016/0014-2999(87)90746-1.
Ro 5-4864 (chlorodiazepam) increased coronary flow in isolated retrograde perfused Langendorff rat heart preparations without affecting heart rate and left ventricular contractility (dP/dt). On the other hand Ro 5-4023 (clonazepam) produced very little effect. PK 11195 which has been shown to inhibit the binding of Ro 5-4864 to cardiac muscle did not antagonize this vasodilatory effect of Ro 5-4864 but increased coronary flow by itself. The data indicate a specific vasodilatory effect of certain benzodiazepines. The mechanism of action remains unknown.
Ro 5-4864（氯地西泮）可增加离体逆行灌注的Langendorff大鼠心脏标本的冠脉血流量，而不影响心率和左心室收缩力（dp/dt）。另一方面，Ro 5-4023（氯硝西泮）的作用很小。PK 11195已被证明可抑制Ro 5-4864与心肌的结合，它并未拮抗Ro 5-4864的这种血管舒张作用，但其自身可增加冠脉血流量。这些数据表明某些苯二氮䓬类药物具有特定的血管舒张作用。其作用机制尚不清楚。
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