Butt T, Ahmad R N, Salman M, Kazmi S Y
Microbiology Department, Armed Forces Institute of Pathology, Rawalpindi, Pakistan.
East Mediterr Health J. 2005 Sep-Nov;11(5-6):1038-44.
We analysed the record of blood cultures carried out at the Armed Forces Institute of Pathology, Rawalpindi between 1996 and 2003. We isolated 477 Salmonella typhi and 410 S. paratyphi A from blood of patients suffering from typhoid fever. We observed a significant shift in the distribution and antimicrobial susceptibility of typhoid salmonellae. The isolation rate of S. typhi fell significantly while S. paratyphi A is emerging as a major pathogen. Resistance to conventional antityphoid drugs in S. typhi decreased dramatically from 80% to 14%, while in S. paratyphi A resistance increased from 14% to 44%. Susceptibility to the fluoroquinolones decreased in both. No resistance to third generation cephalosporins was detected.
我们分析了1996年至2003年间在拉瓦尔品第武装部队病理研究所进行的血培养记录。我们从伤寒热患者的血液中分离出477株伤寒沙门氏菌和410株甲型副伤寒沙门氏菌。我们观察到伤寒沙门氏菌在分布和抗菌药敏性方面发生了显著变化。伤寒沙门氏菌的分离率显著下降，而甲型副伤寒沙门氏菌正成为主要病原体。伤寒沙门氏菌对传统抗伤寒药物的耐药性从80%急剧下降到14%，而甲型副伤寒沙门氏菌的耐药性从14%增加到44%。两种菌对氟喹诺酮类药物的敏感性均降低。未检测到对第三代头孢菌素的耐药性。
