Tavora Fabio, Gonzalez-Cuyar Luis F, Sun Chen-Chih J, Burke Allen, Zhao X Frank
Department of Pathology, University of Maryland School of Medicine, Baltimore, 21201, USA.
Hum Pathol. 2006 Sep;37(9):1233-6. doi: 10.1016/j.humpath.2006.04.009. Epub 2006 Jul 7.
Plasmablastic lymphoma (PBL) of the oral cavity is classified as one subtype of diffuse large B-cell lymphoma that is most commonly seen in patients with human immunodeficiency virus infection. We report a rare case of PBL in the anal canal of a 33-year-old man with human immunodeficiency virus infection. The lymphoma cells were positive for CD138 and weakly positive for CD79a. In addition, these cells were also positive for CD10. The neoplastic cells were positive for Epstein-Barr virus and negative for human herpes virus 8. Review of the English medical literature revealed many more cases of extra-oral PBL. We propose that the term plasmablastic lymphoma of the oral cavity in World Health Organization classification be revised to simply plasmablastic lymphoma, which would include both oral and extra-oral PBLs, and the term to define the primary site of the lymphoma (ie, oral cavity) be dropped from the terminology used in World Health Organization classification.
口腔浆母细胞性淋巴瘤（PBL）被归类为弥漫性大B细胞淋巴瘤的一种亚型，最常见于人类免疫缺陷病毒感染患者。我们报告了一例罕见的发生于一名33岁人类免疫缺陷病毒感染男性肛管的PBL病例。淋巴瘤细胞CD138呈阳性，CD79a呈弱阳性。此外，这些细胞CD10也呈阳性。肿瘤细胞 Epstein-Barr病毒呈阳性，人类疱疹病毒8呈阴性。查阅英文医学文献发现更多口腔外PBL病例。我们建议将世界卫生组织分类中的口腔浆母细胞性淋巴瘤这一术语修订为简单的浆母细胞性淋巴瘤，其中应包括口腔和口腔外PBL，且用于定义淋巴瘤原发部位（即口腔）的术语应从世界卫生组织分类所用术语中删除。
