Sarode S C, Zarkar G A, Desai R S, Sabane V S, Kulkarni M A
Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Maheshnagar, Pimpri, Pune-18, Maharashtra, India.
Int J Oral Maxillofac Surg. 2009 Sep;38(9):993-9. doi: 10.1016/j.ijom.2009.03.720. Epub 2009 May 13.
Plasmablastic lymphoma (PBL) of the oral cavity is an uncommon, recently described B-cell derived lymphoma that is most commonly seen in patients with human immunodeficiency virus (HIV) infections. The authors report a rare case of PBL in the oral cavity of a 40-year-old man with HIV. The lymphoma cells were positive for leukocyte common antigen, CD79a, CD138, Epstein-Barr virus (EBV) and kappa light chain restriction and negative for CD20, CD3, S100, HMB45 and cytokeratins. The lesion regressed after treatment with local radiotherapy and systemic chemotherapy. The features of this rare disease are summarized based on a comprehensive review of the epidemiological, clinical and immunohistochemical findings of previously reported cases.
口腔浆母细胞淋巴瘤（PBL）是一种罕见的、最近才被描述的B细胞来源淋巴瘤，最常见于人类免疫缺陷病毒（HIV）感染患者。作者报告了1例40岁HIV男性患者口腔罕见的PBL病例。淋巴瘤细胞白细胞共同抗原、CD79a、CD138、爱泼斯坦-巴尔病毒（EBV）和κ轻链限制呈阳性，而CD20、CD3、S100、HMB45和细胞角蛋白呈阴性。经局部放疗和全身化疗后病变消退。基于对先前报道病例的流行病学、临床和免疫组化结果的全面回顾，总结了这种罕见疾病的特征。
