Asmar R G, Kerihuel J C, Girerd X J, Safar M E
Department of Internal Medicine, Broussais Hospital, Paris, France.
Am J Cardiol. 1991 Jul 1;68(1):61-4. doi: 10.1016/0002-9149(91)90711-s.
Blood pressure, heart rate, common carotid and brachial arterial hemodynamics using pulsed Doppler flowmetry and pulse wave velocity determinations were evaluated using a double-blind crossover design versus placebo in 14 patients with sustained essential hypertension treated by the selective beta 1 blocking agent bisoprolol. Blood pressure and heart rate significantly decreased after bisoprolol, whereas no significant change occurred in the diameter, the blood flow and in the vascular resistance of the carotid and brachial circulations. Pulse wave velocity significantly decreased in the brachioradial and the carotid femoral areas. The decrease in the latter was -1.6 +/- 0.8 m/s with bisoprolol and -0.06 +/- 0.80 m/s with placebo (p = 0.001). Brachial artery compliance significantly increased from 117 +/- 49 to 205 +/- 84 cm4 x dynes-1 x 10(9) (p = 0.001), indicating that the antihypertensive effect of beta 1 blockade is associated with an improvement in the viscoelastic properties of the brachial artery wall.
采用双盲交叉设计，将14例服用选择性β1阻滞剂比索洛尔治疗的持续性原发性高血压患者与安慰剂进行对比，使用脉冲多普勒血流仪评估血压、心率、颈总动脉和肱动脉血流动力学，并测定脉搏波速度。服用比索洛尔后血压和心率显著降低，而颈动脉和肱动脉循环的直径、血流量及血管阻力无显著变化。肱桡动脉和颈股动脉区域的脉搏波速度显著降低。服用比索洛尔时后者降低值为-1.6±0.8m/s，服用安慰剂时为-0.06±0.80m/s（p=0.001）。肱动脉顺应性从117±49显著增加至205±84cm4×达因-1×10(9)（p=0.001），表明β1受体阻滞的降压作用与肱动脉壁粘弹性特性的改善有关。
