Prince C W, Dickie D, Krumdieck C L
Department of Nutrition Sciences, University of Alabama, Birmingham 35294.
Biochem Biophys Res Commun. 1991 Jun 28;177(3):1205-10. doi: 10.1016/0006-291x(91)90669-x.
Osteopontin (OPN), an extracellular matrix cell adhesion protein, was found to serve as a substrate for the incorporation of radiolabelled putrescine mediated by a commercial preparation of guinea pig liver transglutaminase. Preliminary evidence also suggests that OPN serves as a substrate for the plasma transglutaminase, Factor XIIIa. While the protein substrates to which OPN is linked in vivo have not been identified, it is reasonable to speculate that this capacity of OPN may dictate its extracellular location and thereby affect its role in bone homeostasis, tumorigenesis, metastasis, resistance to bacterial infections or, perhaps, wound repair.
骨桥蛋白（OPN）是一种细胞外基质细胞粘附蛋白，已发现它可作为豚鼠肝脏转谷氨酰胺酶商业制剂介导的放射性标记腐胺掺入的底物。初步证据还表明，OPN可作为血浆转谷氨酰胺酶——因子XIIIa的底物。虽然尚未确定OPN在体内与之相连的蛋白质底物，但合理推测，OPN的这种能力可能决定其细胞外定位，从而影响其在骨稳态、肿瘤发生、转移、抗细菌感染或者伤口修复中的作用。
