Fanger M W, Segal D M, Romet-Lemonne J L
Dept of Microbiology, Dartmouth Medical School, Hanover, NH 03756.
Immunol Today. 1991 Feb;12(2):51-4. doi: 10.1016/0167-5699(91)90156-N.
The Second International Conference on Bispecific Antibodies (BsAbs) and Targeted Cellular Cytotoxicity considered how targeted cytotoxicity can be used (1) to increase understanding of the general mechanisms of cellular cytotoxicity and (2) clinically in the treatment of cancer and infectious disease. BsAbs, the main mediators of targeted cellular cytotoxicity, can be made by chemical crosslinking, by fusing hybridoma cells and by molecular genetic approaches. BsAbs bind to target cells via one V region and trigger molecules such as T-cell receptors (TCRs) or FcR for IgG (Fc gamma R) on cytotoxic cells via their other V region. This linking of triggering structures to target cells induces target cell lysis and provides important clues to the signals used to elicit the lytic process.
第二届双特异性抗体（BsAbs）与靶向细胞毒性国际会议探讨了如何利用靶向细胞毒性：（1）增进对细胞毒性一般机制的理解；（2）在癌症和传染病治疗中的临床应用。BsAbs作为靶向细胞毒性的主要介导物，可通过化学交联、杂交瘤细胞融合及分子遗传学方法制备。BsAbs通过一个V区与靶细胞结合，并通过其另一个V区触发细胞毒性细胞上的分子，如T细胞受体（TCRs）或IgG的Fc受体（FcγR）。这种触发结构与靶细胞的连接诱导靶细胞裂解，并为引发裂解过程所用的信号提供重要线索。
