Accolla R S, Auffray C, Singer D S, Guardiola J
Istituto di Scienze Immunologiche, Università di Verona, Italy.
Immunol Today. 1991 Apr;12(4):97-9. doi: 10.1016/0167-5699(91)90090-G.
Antigenic peptides become associated with major histocompatibility complex (MHC) class I and class II surface antigens, are then presented to T cells and thereby elicit an antigen-specific cellular or humoral immune response. MHC molecules are genetically heterogeneous and polymorphic; their structure is therefore relevant to modulation of the immune system. The selective pressure resulting from this modulation is in turn the main driving force for the evolution of the complex genetic system. The density of MHC molecules on the cell surface is another parameter that influences immune responsiveness. The study of the evolution and regulation of MHC genes is, therefore, of great interest. These and other themes were discussed at the Third IIGB Workshop* which was recently held in Capri.
抗原肽与主要组织相容性复合体（MHC）I类和II类表面抗原结合，然后呈递给T细胞，从而引发抗原特异性细胞免疫或体液免疫反应。MHC分子具有遗传异质性和多态性；因此，它们的结构与免疫系统的调节相关。这种调节产生的选择压力反过来又是复杂遗传系统进化的主要驱动力。细胞表面MHC分子的密度是影响免疫反应性的另一个参数。因此，对MHC基因的进化和调控的研究备受关注。最近在卡普里岛举行的第三届IIGB研讨会上*讨论了这些以及其他主题。
