Salter-Cid L, Flajnik M F
Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33101, USA.
Crit Rev Immunol. 1995;15(1):31-75. doi: 10.1615/critrevimmunol.v15.i1.20.
The ontogeny and evolution of the major histocompatibility complex (MHC) are blossoming fields that grant insight into the origins of the adaptive immune system and into the strategies adopted by particular groups of vertebrates for expression of MHC during development. This review surveys general topics concerning MHC evolution, with special emphasis on the significance of linkage of gene families within the MHC; a model is proposed in which the MHC class III region is the "primordial immune complex" with its members giving rise to classical MHC molecules. The developmental expression of MHC, both of the classical and non-classical genes, is described in detail with a concentration on differential expression by extraembryonic tissues in mammals and by tissues in "transition" during metamorphosis in amphibians.
主要组织相容性复合体（MHC）的个体发生和进化是蓬勃发展的领域，有助于深入了解适应性免疫系统的起源以及特定脊椎动物群体在发育过程中表达MHC所采用的策略。本综述概述了有关MHC进化的一般主题，特别强调了MHC内基因家族连锁的重要性；提出了一个模型，其中MHC III类区域是“原始免疫复合体”，其成员产生经典的MHC分子。详细描述了经典和非经典基因的MHC发育表达，重点关注哺乳动物中胚外组织和两栖动物变态过程中“过渡”组织的差异表达。
