B 系急性淋巴细胞白血病维持治疗期间弥漫性大 B 细胞淋巴瘤的发生

Development of diffuse large B cell lymphoma during the maintenance therapy for B-lineage acute lymphoblastic leukemia.

作者信息

Kato Itaru, Manabe Atsushi, Aoyama Chiaki, Kamiya Takahiro, Morimoto Tsuyoshi, Matsufuji Hiroshi, Suzuki Koyu, Kitagawa Yoshiro, Hori Toshinori, Tsurusawa Masahito, Kiyokawa Nobutaka, Junichiro Fujimoto, Hosoya Ryota

机构信息

Department of Pediatrics, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan.

出版信息

Pediatr Blood Cancer. 2007 Feb;48(2):230-2. doi: 10.1002/pbc.20909.

DOI:10.1002/pbc.20909

PMID:16763979

Abstract

Non-Hodgkin lymphoma (NHL) is a very rare complication of acute lymphoblastic leukemia (ALL). A Japanese boy presented with B-lineage ALL at the age of 2.5. He was treated with chemotherapy for standard-risk ALL. While he was receiving maintenance treatment 2 years and 9 months after the diagnosis of ALL, diffuse large B cell lymphoma (DLBL) was diagnosed from a biopsy of an abdominal mass. DLBL was treated by surgical resection followed by chemotherapy for 6 months. The patient has been free from the recurrence of ALL or DLBL for 16 months after the development of DLBL.

摘要

非霍奇金淋巴瘤（NHL）是急性淋巴细胞白血病（ALL）一种非常罕见的并发症。一名日本男孩在2.5岁时被诊断为B系急性淋巴细胞白血病。他接受了针对低危急性淋巴细胞白血病的化疗。在急性淋巴细胞白血病诊断2年9个月后接受维持治疗期间，通过腹部肿块活检诊断出弥漫性大B细胞淋巴瘤（DLBL）。弥漫性大B细胞淋巴瘤通过手术切除，随后进行了6个月的化疗。自弥漫性大B细胞淋巴瘤发病后16个月，该患者未出现急性淋巴细胞白血病或弥漫性大B细胞淋巴瘤复发。