Yamanaka J, Baker M, Metcalfe S, Hutson J M
Surgical Research Laboratory, Royal Children's Hospital Research Foundation, Melbourne, Australia.
J Pediatr Surg. 1991 May;26(5):621-3. doi: 10.1016/0022-3468(91)90723-7.
Serum levels of Mullerian inhibiting substance (MIS) were measured in boys with cryptorchidism (n = 104) and paired, age-matched controls (n = 104) using an enzyme immunoassay. Control MIS levels were high during the first year of life with a peak level at 4 to 12 months, subsequently diminishing with age. MIS levels in patients with undescended testes also declined with age, although a surge was not found in the first year. Mean MIS concentration of cryptorchid boys was significantly lower than controls (P less than .001). There was a significant reduction of the mean MIS level in children with bilateral cryptorchidism compared with those with unilateral undescended testis (P less than .05). These differences might support the hypothesis that MIS initiates transabdominal testicular descent. However, because most undescended testes are probably the result of anatomical or functional abnormalities during transinguinal testicular descent, differences in MIS levels more likely result from secondary testicular degeneration. In the future, MIS immunoassay should play an important role in the investigation of gonadal function in boys with various genital disorders, including cryptorchidism.
采用酶免疫分析法测定了104例隐睾症男孩和104例年龄匹配的对照男孩的血清苗勒管抑制物质（MIS）水平。对照者的MIS水平在出生后第一年较高，在4至12个月时达到峰值水平，随后随年龄下降。隐睾症患者的MIS水平也随年龄下降，尽管在第一年未发现激增现象。隐睾症男孩的平均MIS浓度显著低于对照组（P<0.001）。与单侧隐睾症患儿相比，双侧隐睾症患儿的平均MIS水平显著降低（P<0.05）。这些差异可能支持MIS启动经腹睾丸下降的假说。然而，由于大多数隐睾症可能是经腹股沟睾丸下降过程中解剖或功能异常的结果，MIS水平的差异更可能是继发性睾丸退变所致。未来，MIS免疫分析在患有包括隐睾症在内的各种生殖器疾病的男孩性腺功能研究中应发挥重要作用。
