Ong C, Hasthorpe S, Hutson J M
F. Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
Pediatr Surg Int. 2005 Apr;21(4):240-54. doi: 10.1007/s00383-005-1382-0. Epub 2005 Feb 23.
Germ cell development is an active process in normal testes during the first 4 years after birth, with transformation of the neonatal gonocytes into adult dark spermatogonia and then primary spermatocytes. The hormonal regulation of these changes is not fully understood, with evidence both for and against a role for gonadotrophins and androgens. Early surgical intervention in infancy aims to prevent or reverse germ cell maldevelopment. Although hormonal treatment for maldescent has been shown to be ineffective, there is still controversy over whether it may be useful as an adjunct to surgery to stimulate germ cells. Current evidence suggests that hormonal therapy may not stimulate transformation of neonatal gonocytes but may trigger prepubertal mitosis of primary spermatocytes. Further studies are required to determine the role of hormone treatment on germ cell development.
在出生后的头4年里，生殖细胞发育在正常睾丸中是一个活跃的过程，新生儿生殖母细胞会转化为成年暗色精原细胞，然后再转化为初级精母细胞。这些变化的激素调节尚未完全明确，有证据支持和反对促性腺激素和雄激素发挥作用。婴儿期的早期手术干预旨在预防或逆转生殖细胞发育不良。虽然已证明激素治疗隐睾无效，但对于其作为手术辅助手段刺激生殖细胞是否有用仍存在争议。目前的证据表明，激素疗法可能不会刺激新生儿生殖母细胞的转化，但可能会触发青春期前初级精母细胞的有丝分裂。需要进一步研究以确定激素治疗对生殖细胞发育的作用。
