Sloka J S, Pryse-Phillips W E M, Stefanelli M
Faculty of Medicine (Neurology), Memorial University of Newfoundland, 108 Moss Heather Dr., St. John's, NL, Canada.
Mult Scler. 2006 Jun;12(3):333-9. doi: 10.1191/135248506ms1267oa.
Previously, multiple sclerosis (MS) has been thought to be associated with changes in hormone levels. This study investigates the association between the age of menarche and the age of onset of the first symptoms of MS.
A complete list of patients diagnosed with MS in the province of Newfoundland and Labrador was constructed. The age of menarche for our entire relapsing remitting female MS (RRMS) population was requested by mailout survey. Age of symptom onset was ascertained by chart review.
A 74% rate of return on the survey results was obtained (150 RRMS patients). A linear regression model demonstrated that the age of first symptoms increased by 1.16 years as the age of menarche increased by one year (R2 = 0.69, P = 0.04). Another analysis showed that the average age of first symptoms for women with reported menarche from 10 to 12 years was 28.96 years compared with 31.83 years for a reported menarche from 13 to 15 years, a significant difference (P = 0.047, t-test).
This study suggests that menarche may be related to the pathogenesis of MS.
此前，多发性硬化症（MS）被认为与激素水平变化有关。本研究调查月经初潮年龄与MS首次症状发作年龄之间的关联。
构建了纽芬兰和拉布拉多省确诊为MS的患者完整名单。通过邮寄调查获取我们整个复发缓解型女性MS（RRMS）人群的月经初潮年龄。通过查阅病历确定症状发作年龄。
调查结果的回复率为74%（150例RRMS患者）。线性回归模型显示，月经初潮年龄每增加1岁，首次症状发作年龄增加1.16岁（R2 = 0.69，P = 0.04）。另一项分析表明，报告月经初潮年龄在10至12岁的女性首次症状发作的平均年龄为28.96岁，而报告月经初潮年龄在13至15岁的女性为31.83岁，差异有统计学意义（P = 0.047，t检验）。
本研究表明月经初潮可能与MS的发病机制有关。
