Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Research Center for Immunodeficiencies (RCID), Tehran University of Medical Sciences (TUMS), Tehran, Iran.
BMC Neurol. 2019 Nov 14;19(1):286. doi: 10.1186/s12883-019-1473-5.
Some studies have looked at the age at menarche and risk of Multiple Sclerosis (MS).We aimed to conduct a systematic review and meta-analysis to estimate a pooled odds ratio of developing MS by increasing age at menarche.
We searched PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, google scholar and gray literature (references of references, congress abstracts) up to 10th April 2019.
The literature search found 312 articles. After eliminating duplicates, reviews, case reports and trials, 18 articles remained. Three articles were ultimately included in the final analysis. Two studies were from Iran, and one from Canada. The pooled odds ratio (OR) for increasing 1 year of age at menarche was 0.88 (95% CI:0.82-0.94), with no significant heterogeneity (I = 49%, p = 0.1). Mean age at menarche was significantly different between case and control groups (mean difference = - 0.22, 95% CI = -0.42,-0.02).
The result of this systematic review showed that the risk of MS decreases by increasing age at menarche.
一些研究探讨了初潮年龄与多发性硬化症（MS）风险之间的关系。我们旨在进行系统评价和荟萃分析，以估计初潮年龄每增加 1 岁，患 MS 的汇总优势比。
我们检索了 PubMed、Scopus、EMBASE、CINAHL、Web of Science、Ovid、google scholar 和灰色文献（参考文献、会议摘要），检索时间截至 2019 年 4 月 10 日。
文献检索共发现 312 篇文章。剔除重复文献、综述、病例报告和试验后，仍有 18 篇文章。最终有 3 篇文章纳入最终分析。其中 2 项研究来自伊朗，1 项来自加拿大。初潮年龄每增加 1 岁，患病风险的汇总优势比（OR）为 0.88（95%CI：0.82-0.94），无显著异质性（I = 49%，p = 0.1）。病例组和对照组的初潮年龄差异具有统计学意义（平均差异 = -0.22，95%CI = -0.42，-0.02）。
本系统评价的结果表明，初潮年龄的增加与 MS 患病风险的降低相关。
