Jin Hua, Hampton Atkinson J, Yu Xin, Heaton Robert K, Shi Chuan, Marcotte Thomas P, Young Corinna, Sadek Joseph, Wu Zunyou, Grant Igor
HIV Neurobehavioral Research Center, University of California at San Diego, 150 W. Washington, 2nd Floor, San Diego, CA 92103, USA.
J Affect Disord. 2006 Aug;94(1-3):269-75. doi: 10.1016/j.jad.2006.04.013. Epub 2006 Jun 9.
This pilot study examined rates of major depression and suicidality and their associations with daily functioning in HIV infected (HIV+) and uninfected (HIV-) persons in China.
HIV+ participants (N=28) and demographically matched HIV- controls (N=23) completed the Chinese Composite International Diagnostic Interview to determine lifetime rates of major depressive disorder (MDD) and suicidality. Current mood and suicidal ideation were assessed with the Beck Depression Inventory-I. The impact of depression and HIV infection on daily functioning was measured by an Activity of Daily Living questionnaire.
Mean duration of known HIV+ status was 2 years. Almost 79% (n=22) of HIV+ but just 4% (n=1) of HIV- groups reported lifetime major depression. Of the 22 HIV+ individuals with lifetime MDD, only one had onset before learning of HIV status. The remainder developed MDD within 6 months after testing HIV positive. In those HIV+ subjects who met MDD criteria after HIV diagnosis, only two (9%) had received depression treatment, yet four (18%) had persisting active suicidal thoughts. Depression and HIV+ status independently predicted worse daily functioning.
Representativeness is limited in this small sample of convenience.
This preliminary study presents evidence of high rates of major depression and suicidality in HIV-infected persons in China. Despite this, few had sought mental health assistance, suggesting a need to increase awareness of psychiatric comorbidity and access to mental health services.
这项试点研究调查了中国艾滋病毒感染者(HIV+)和未感染者(HIV-)中重度抑郁症和自杀倾向的发生率及其与日常功能的关联。
HIV+参与者(N = 28)和人口统计学匹配的HIV-对照组(N = 23)完成了中国综合国际诊断访谈,以确定重度抑郁症(MDD)和自杀倾向的终生发生率。使用贝克抑郁量表-I评估当前情绪和自杀意念。通过日常生活活动问卷测量抑郁症和艾滋病毒感染对日常功能的影响。
已知HIV+状态的平均持续时间为2年。几乎79%(n = 22)的HIV+组报告有终生重度抑郁症,而HIV-组中只有4%(n = 1)报告有。在22名有终生MDD的HIV+个体中,只有1人在得知艾滋病毒状态之前发病。其余在检测出HIV阳性后的6个月内患上MDD。在那些艾滋病毒诊断后符合MDD标准的HIV+受试者中,只有2人(9%)接受过抑郁症治疗,但有4人(18%)有持续的积极自杀念头。抑郁症和HIV+状态独立预测日常功能较差。
这个小样本的便利性使其代表性有限。
这项初步研究提供了中国艾滋病毒感染者中重度抑郁症和自杀倾向发生率较高的证据。尽管如此,很少有人寻求心理健康援助,这表明需要提高对精神疾病共病的认识并增加获得心理健康服务的机会。