Colombo Jorge A, Bentham Carolina
Unidad de Neurobiología Aplicada (UNA) (CEMIC), Av. Galván 4102, 1431 Ciudad de, Buenos Aires, Argentina.
Brain Res. 2006 Jul 19;1100(1):93-103. doi: 10.1016/j.brainres.2006.04.116. Epub 2006 Jun 12.
An immunohistochemical analysis of brain subcortical white matter astroglia from human (infant, adult) and adult monkey (Cebus apella, Macaca nemestrina) cases without any known neurological disease, is described. Expression of synaptic vesicle-associated proteins, excitatory amino acid transporters (EAAT1 and EAAT2) and GABAA Ralpha2 receptor produced coarse punctate labeling in human adult white matter astrocytes. A finer, generalized, punctate labeling was observed in human infants and adult C. apella monkeys. Labeling of neuronal somata and processes with microtubule-associated proteins (MAP2a-c) and neuron nuclear (NeuN) antibodies, was also observed in subcortical white matter of humans and monkeys. Results suggest competence of subcortical white matter astroglia of the primate brain to participate in various transmitter regulatory pathways. It is also proposed that, collectively with resident neurons, they may exert some role in affecting the transfer of information that takes place through the various associational and projecting fiber systems coursing through this brain compartment.
本文描述了对无任何已知神经疾病的人类（婴儿、成人）和成年猴子（僧帽猴、豚尾猴）大脑皮质下白质星形胶质细胞进行的免疫组织化学分析。突触小泡相关蛋白、兴奋性氨基酸转运体（EAAT1和EAAT2）以及GABAA Rα2受体在人类成年白质星形胶质细胞中呈粗大的点状标记。在人类婴儿和成年僧帽猴中观察到更精细、广泛的点状标记。在人类和猴子的皮质下白质中也观察到用微管相关蛋白（MAP2a - c）和神经元核（NeuN）抗体对神经元胞体和突起的标记。结果表明灵长类动物大脑皮质下白质星形胶质细胞有能力参与各种递质调节途径。还提出，它们与驻留神经元一起，可能在影响通过贯穿该脑区的各种联合和投射纤维系统进行的信息传递方面发挥一定作用。
