Knutsson Nina, Jansson Ulla-Britt, Alm Bernt
Primary Health and Medical Care, Child Health Centre, Munkebäckstorg, S-416 73 Göteborg, Sweden.
Vaccine. 2006 Jul 26;24(31-32):5800-5. doi: 10.1016/j.vaccine.2006.05.004. Epub 2006 May 22.
The aim of this study was to investigate whether, the vaccine Priorix causes less immediate injection pain than MMR-II in vaccination of infants aged 18-24 months who were offered vaccine against measles, mumps and rubella. The infants were randomised into one of the two vaccine groups (Priorix/MMR-II in a double-blind study. One observer assessed pain, using CHEOPS (Children's Hospital Eastern Ontario Pain scale), and the parent used the Visual Analogue Pain scale (VAS). Pain assessment was made in 295 infants. Mean age was 19.08 months. Mean VAS value was 2.3/5.2 for Priorix and MMR-II, respectively (p<0.001). Mean CHEOPS value was 1.9/6.1 for Priorix and MMR-II, respectively (p<0.001). The study shows that Priorix gives less immediate injection pain than MMR-II.
本研究的目的是调查在为18 - 24个月大的婴儿接种麻疹、腮腺炎和风疹疫苗时，Priorix疫苗引起的即时注射疼痛是否比MMR-II疫苗少。这些婴儿被随机分为两个疫苗组之一（在一项双盲研究中使用Priorix/MMR-II）。一名观察者使用CHEOPS（安大略省东部儿童医院疼痛量表）评估疼痛，家长使用视觉模拟疼痛量表（VAS）。对295名婴儿进行了疼痛评估。平均年龄为19.08个月。Priorix和MMR-II的平均VAS值分别为2.3/5.2（p<0.001）。Priorix和MMR-II的平均CHEOPS值分别为1.9/6.1（p<0.001）。该研究表明，Priorix引起的即时注射疼痛比MMR-II少。
