DRB基因分型支持与DR3相关的胰岛素依赖型糖尿病易感性的隐性遗传。
DRB genotyping supports recessive inheritance of DR3-associated susceptibility to insulin-dependent diabetes mellitus.
作者信息
Jenkins D, Fletcher J, Penny M A, Mijovic C H, Jacobs K H, Bradwell A R, Barnett A H
机构信息
Department of Medicine, University of Birmingham, England.
出版信息
Am J Hum Genet. 1991 Jul;49(1):49-53.
The mode of inheritance of HLA-associated susceptibility to insulin-dependent diabetes mellitus was investigated by the antigen genotype frequency among patients method in a white Caucasian population and a North Indian Asian population. DR genotypes were determined by DRB/DQB RFLP analysis. In white Caucasians, simple recessive and simple additive inheritance of a single HLA-associated disease susceptibility allele were rejected (P less than .025 and P less than 10(-6), respectively). The data were compatible with a three-allele model of disease susceptibility. In North Indian Asians, simple additive inheritance was rejected (P less than 10(-6)). The observed genotype frequencies were compatible with a single DR3-associated disease susceptibility allele which is inherited recessively. These data show that study of DR genotypes in populations of different ethnic origins may further the understanding of inherited susceptibility to insulin-dependent diabetes mellitus.
通过患者抗原基因型频率法，在白种人群体和北印度亚裔人群体中研究了与胰岛素依赖型糖尿病相关的HLA易感性的遗传模式。通过DRB/DQB RFLP分析确定DR基因型。在白种人中，单一HLA相关疾病易感性等位基因的简单隐性遗传和简单加性遗传被排除（P分别小于0.025和P小于10^(-6)）。数据与疾病易感性的三等位基因模型相符。在北印度亚裔中，简单加性遗传被排除（P小于10^(-6)）。观察到的基因型频率与单一DR3相关疾病易感性等位基因相符，该等位基因呈隐性遗传。这些数据表明，对不同种族起源人群的DR基因型进行研究可能有助于进一步理解胰岛素依赖型糖尿病的遗传易感性。
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