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Susceptibility to type 1 (insulin-dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4?

作者信息

Mijovic C H, Jenkins D, Penny M A

机构信息

Department of Medicine, University of Birmingham, UK.

出版信息

Diabetologia. 1993 Nov;36(11):1210-1. doi: 10.1007/BF00401069.

DOI:10.1007/BF00401069
PMID:8270139
Abstract
摘要

相似文献

1
Susceptibility to type 1 (insulin-dependent) diabetes mellitus is determined by MHC class II molecules. What about DR4?1型(胰岛素依赖型)糖尿病的易感性由MHCⅡ类分子决定。那DR4呢?
Diabetologia. 1993 Nov;36(11):1210-1. doi: 10.1007/BF00401069.
2
Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.I类人类白细胞抗原与胰岛素依赖型糖尿病的发病年龄相关,而II类人类白细胞抗原则赋予对胰岛素依赖型糖尿病的易感性。
Diabetologia. 1995 Dec;38(12):1493-5. doi: 10.1007/BF00400620.
3
Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4.西班牙人群中的1型糖尿病:除II类HLA-DR3和-DR4之外的其他因素。
BMC Genomics. 2005 Apr 20;6:56. doi: 10.1186/1471-2164-6-56.
4
In Finland insulin gene region encoded susceptibility to IDDM exerts maximum effect when there is low HLA-DR associated risk. DiMe (Childhood Diabetes in Finland) Study Group.在芬兰,胰岛素基因区域编码的对胰岛素依赖型糖尿病的易感性,在HLA - DR相关风险较低时发挥最大作用。芬兰儿童糖尿病(DiMe)研究小组。
Diabetologia. 1995 Oct;38(10):1223-9. doi: 10.1007/BF00422373.
5
Genetic susceptibility linked to DR4 haplotypes in diabetes of type-1a or associated with polyendocrinopathies (type-1b). The Diabetes Study Group from West France.
Tissue Antigens. 1991 Oct;38(4):183-5. doi: 10.1111/j.1399-0039.1991.tb01894.x.
6
HLA-associated susceptibility to type 2 (non-insulin-dependent) diabetes mellitus: the Wadena City Health Study.HLA与2型(非胰岛素依赖型)糖尿病易感性:瓦迪纳市健康研究
Diabetologia. 1993 Mar;36(3):234-8. doi: 10.1007/BF00399956.
7
Molecular aspects of HLA class II and some autoimmune diseases.人类白细胞抗原(HLA)II类分子与某些自身免疫性疾病的分子机制
Eur J Immunogenet. 1993 Jun;20(3):153-64. doi: 10.1111/j.1744-313x.1993.tb00106.x.
8
Genetic analysis of HLA class II alleles and susceptibility to type 1 (insulin-dependent) diabetes mellitus in Japanese subjects.
Diabetologia. 1992 May;35(5):419-24. doi: 10.1007/BF02342437.
9
Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes.1型糖尿病与2型糖尿病之间可能存在的人类白细胞抗原介导的基因相互作用。
J Clin Endocrinol Metab. 2001 Feb;86(2):574-82. doi: 10.1210/jcem.86.2.7170.
10
Does the locus on chromosome 11 implicated in susceptibility to HLA-DR4 dependent type I diabetes mellitus also affect susceptibility to rheumatoid arthritis?11号染色体上与HLA - DR4依赖的I型糖尿病易感性相关的基因座是否也会影响类风湿性关节炎的易感性?
Ann Rheum Dis. 1992 Nov;51(11):1250-1. doi: 10.1136/ard.51.11.1250.

引用本文的文献

1
Genetic predisposition to IDDM.胰岛素依赖型糖尿病的遗传易感性。
Clin Rev Allergy Immunol. 2000 Dec;19(3):227-46. doi: 10.1385/CRIAI:19:3:227.
2
Relationships among 64k autoantibodies, pancreatic beta-cell function, HLA-DR antigens and HLA-DQ genes in patients with insulin-dependent diabetes mellitus in Korea.韩国胰岛素依赖型糖尿病患者中64k自身抗体、胰岛β细胞功能、HLA - DR抗原与HLA - DQ基因之间的关系。
Korean J Intern Med. 1995 Jan;10(1):1-9. doi: 10.3904/kjim.1995.10.1.1.

本文引用的文献

1
HLA-DQ allelic polymorphisms constrain patterns of class II heterodimer formation.人类白细胞抗原-DQ等位基因多态性限制了II类异二聚体的形成模式。
J Immunol. 1993 Mar 15;150(6):2263-72.
2
Particular HLA-DQ molecules play a dominant role in determining susceptibility or resistance to type 1 (insulin-dependent) diabetes mellitus.特定的人类白细胞抗原-DQ分子在决定对1型(胰岛素依赖型)糖尿病的易感性或抵抗力方面起主导作用。
Diabetologia. 1993 May;36(5):371-7. doi: 10.1007/BF00402270.
3
Transcomplementation of HLA genes in IDDM. HLA-DQ alpha- and beta-chains produce hybrid molecules in DR3/4 heterozygotes.
胰岛素依赖型糖尿病中HLA基因的转互补作用。HLA-DQα链和β链在DR3/4杂合子中产生杂交分子。
Diabetes. 1987 Jan;36(1):114-7. doi: 10.2337/diab.36.1.114.
4
Association of HLA-DQw3 (TA10-) with type I diabetes occurs with DR3/4 but not DR1/4 patients.HLA-DQw3(TA10-)与I型糖尿病的关联发生在DR3/4患者中,而DR1/4患者则不然。
Diabetes. 1988 Jul;37(7):926-9. doi: 10.2337/diab.37.7.926.
5
A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles.糖尿病易感HLA单倍型最好由HLA-DR和-DQ等位基因的组合来定义。
J Clin Invest. 1989 Mar;83(3):830-5. doi: 10.1172/JCI113965.
6
HLA-DQ beta sequence polymorphism and genetic susceptibility to IDDM.HLA-DQβ序列多态性与胰岛素依赖型糖尿病的遗传易感性
Diabetes. 1990 Jan;39(1):96-103. doi: 10.2337/diacare.39.1.96.
7
Prevention of insulin-dependent diabetes mellitus in non-obese diabetic mice by transgenes encoding modified I-A beta-chain or normal I-E alpha-chain.通过编码修饰的I-Aβ链或正常I-Eα链的转基因预防非肥胖糖尿病小鼠的胰岛素依赖型糖尿病
Nature. 1990 Jun 21;345(6277):727-9. doi: 10.1038/345727a0.
8
Genetics of diabetes. Trans-racial gene mapping studies.糖尿病遗传学。跨种族基因定位研究。
Baillieres Clin Endocrinol Metab. 1991 Jun;5(2):321-40. doi: 10.1016/s0950-351x(05)80130-2.
9
DRB genotyping supports recessive inheritance of DR3-associated susceptibility to insulin-dependent diabetes mellitus.DRB基因分型支持与DR3相关的胰岛素依赖型糖尿病易感性的隐性遗传。
Am J Hum Genet. 1991 Jul;49(1):49-53.
10
Susceptibility to IDDM in a Chinese population. Role of HLA class II alleles.中国人群中胰岛素依赖型糖尿病的易感性。HLA II类等位基因的作用。
Diabetes. 1992 Aug;41(8):914-9. doi: 10.2337/diab.41.8.914.