Papagrigorakis Manolis J, Synodinos Philippos N, Yapijakis Christos
Department of Orthodontics, Dental School, University of Athens, 2 Thivon str., 11527 Goudi, Athens, Greece.
Infect Genet Evol. 2007 Jan;7(1):126-7. doi: 10.1016/j.meegid.2006.04.006. Epub 2006 Jun 12.
In contrast to other serotypes of Salmonella enterica, S. Typhi is exclusively adapted to human hosts. Recently, S. Typhi was identified in ancient skeletal material, thereby incriminating typhoid fever for the Plague of Athens. Since, according to Thucydides' report, animals were also affected by the disease, a working hypothesis is constituted that the causative agent of the Plague might be the anticipated original strain of S. Typhi, purportedly capable of infecting animals as well as humans. Possible future sequencing of the discovered ancient strain of S. Typhi may help towards identifying its genomic differences responsible for its modern specification to humans.
与肠炎沙门氏菌的其他血清型不同，伤寒沙门氏菌仅适应人类宿主。最近，在古代骨骼材料中发现了伤寒沙门氏菌，因此将雅典瘟疫归咎于伤寒热。由于根据修昔底德的报告，动物也受到了这种疾病的影响，因此形成了一个可行的假设，即这场瘟疫的病原体可能是预期的伤寒沙门氏菌原始菌株，据称它能够感染动物和人类。未来对发现的古代伤寒沙门氏菌菌株进行测序，可能有助于确定其导致现代仅适应人类特性的基因组差异。
