小梁切除术中结膜下注射丝裂霉素C后角膜缘干细胞缺乏
Limbal stem cell deficiency after subconjunctival mitomycin C injection for trabeculectomy.
作者信息
Sauder Gangolf, Jonas Jost B
机构信息
Department of Ophthalmology, Faculty of Clinical Medicine Mannheim of the University Heidelberg, Germany.
出版信息
Am J Ophthalmol. 2006 Jun;141(6):1129-30. doi: 10.1016/j.ajo.2006.01.018.
PURPOSE
To report on severe limbus cell insufficiency after trabeculectomy with subconjunctival injection of mitomycin C.
DESIGN
Interventional small case-series.
METHODS
Seven consecutive Caucasian patients (seven eyes) underwent penetrating trabeculectomy that included subconjunctival injection of 0.1 to 0.2 ml of mitomycin C (0.2 mg/ml) at the 12 o'clock position.
RESULTS
All patients with a follow-up time of >1.5 years (n = 3 eyes; 43%) experienced marked ocular surface problems that included corneal thinning (n = 1) and scleral melting (n = 2). Four patients (57%) with a follow-up time of <14 months did not show complications that were attributable to the subconjunctival application of mitomycin.
CONCLUSIONS
Because limbal stem cell deficiency may be a late complication of subconjunctival mitomycin C injection, subconjunctival injection of mitomycin C may be avoided in routine antiglaucomatous filtering surgery.
目的
报告小梁切除联合结膜下注射丝裂霉素C后发生的严重角膜缘细胞功能不全。
设计
介入性小病例系列。
方法
连续7例白种人患者（7只眼）接受穿透性小梁切除术，术中在12点位结膜下注射0.1至0.2 ml丝裂霉素C（0.2 mg/ml）。
结果
所有随访时间>1.5年的患者（n = 3只眼；43%）出现明显的眼表问题，包括角膜变薄（n = 1）和巩膜融解（n = 2）。4例随访时间<14个月的患者（57%）未出现与结膜下应用丝裂霉素相关的并发症。
结论
由于角膜缘干细胞缺乏可能是结膜下注射丝裂霉素C的晚期并发症，因此在常规抗青光眼滤过手术中可避免结膜下注射丝裂霉素C。
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