Pirouzian A, O'Halloran H, Scher C, Jockin Y
San Diego Children's Hospital, San Diego, CA 92123, USA.
Ophthalmologica. 2006;220(6):406-8. doi: 10.1159/000095870.
A case of early-onset sclerolimbal ectasia following low-dose topical mitomycin C application during uveitic glaucoma surgery is reported. Intraoperative and postoperative clinical courses were consistent with sclerolimbal ectasia. Adjunctive utilization of intraoperative low-dose 0.02% mitomycin C for the management of chronic uveitic glaucoma patients who are under concomitant systemic immunosuppressive regimen may enhance the risk of subacute postoperative sclerolimbal ectasia. Mitomycin C concentrations < 0.02%, decreased scleral exposure time, and a strict informed consent policy are strongly recommended in this subset of uveitic patients.
本文报告了1例葡萄膜炎性青光眼手术中应用低剂量局部丝裂霉素C后发生早发性巩膜角膜扩张的病例。术中及术后临床病程与巩膜角膜扩张相符。对于正在接受全身免疫抑制治疗的慢性葡萄膜炎性青光眼患者,术中辅助使用低剂量0.02%丝裂霉素C可能会增加术后亚急性巩膜角膜扩张的风险。强烈建议在这类葡萄膜炎患者中使用浓度<0.02%的丝裂霉素C、缩短巩膜暴露时间并采取严格的知情同意政策。