Antoni M H, Schneiderman N, Klimas N, LaPerriere A, Ironson G, Fletcher M A
Department of Psychology, University of Miami, Coral Gables, FL 33124.
Biol Psychiatry. 1991 May 15;29(10):1023-41. doi: 10.1016/0006-3223(91)90359-t.
The present study concurrently measured psychological distress (state anxiety, depression, confusion, and intrusive thoughts), neuroendocrine (plasma cortisol concentrations), and immunologic [lymphocyte proliferative responses to phytohemagglutinin (PHA) and pokeweed mitogen (PWM)] changes in the 5-week periods preceding and following serostatus notification among asymptomatic Human Immunodeficiency Virus-type 1 (HIV-1) seropositive and seronegative gay men. Seropositives, as opposed to seronegatives, showed a disparity in predicted relationships among distress, cortisol, and immunologic measures across the prenotification to postnotification period. Individual difference analyses suggested that among seropositives, in contrast to seronegatives, plasma cortisol concentrations were negatively correlated with psychological distress and positively correlated with responses to PHA (assessed at study entry and after serostatus notification). This pattern in seropositives could not be explained by differences in prenotification perceived risk of infectivity, extraneous environmental stressors, or CD4 cell counts within the seropositive group.
本研究同时测量了无症状的1型人类免疫缺陷病毒（HIV-1）血清阳性和血清阴性男同性恋者在血清状态告知前后5周内的心理困扰（状态焦虑、抑郁、困惑和侵入性思维）、神经内分泌（血浆皮质醇浓度）以及免疫[淋巴细胞对植物血凝素（PHA）和商陆有丝分裂原（PWM）的增殖反应]变化。与血清阴性者相比，血清阳性者在告知前到告知后的时间段内，心理困扰、皮质醇和免疫指标之间的预测关系存在差异。个体差异分析表明，与血清阴性者相比，血清阳性者中血浆皮质醇浓度与心理困扰呈负相关，与对PHA的反应呈正相关（在研究开始时和血清状态告知后进行评估）。血清阳性者的这种模式无法用告知前感知到的感染风险差异、外部环境应激源或血清阳性组内的CD4细胞计数差异来解释。
