Antoni M H, Baggett L, Ironson G, LaPerriere A, August S, Klimas N, Schneiderman N, Fletcher M A
Department of Psychology, University of Miami, Coral Gables, Florida 33124.
J Consult Clin Psychol. 1991 Dec;59(6):906-15. doi: 10.1037//0022-006x.59.6.906.
Forty-seven asymptomatic, healthy gay men were randomly assigned to a cognitive-behavioral stress management (CBSM) condition or an assessment-only control group 5 weeks before being notified of their HIV-1 antibody status. Seventy-two hours before and 1 week after serostatus notification, blood samples and psychometric data were collected. Control subjects showed significant increases in depression, but only slight decrements in mitogen responsivity and lymphocyte cell counts pre- to postnotification of seropositivity. Seropositive CBSM Ss did not show significant pre-post changes in depression, but did reveal significant increases in helper-inducer (CD4) and natural killer (CD56) cell counts as well as a slight increment in proliferative responses to phytohemagglutinin (PHA). Individual difference analyses suggest that the psychological buffering and immunomodulating effects of the CBSM manipulation may be attributable, in part, to relaxation skills learned and practiced or to a general willingness to comply with the intervention guidelines.
47名无症状的健康男同性恋者在得知其HIV-1抗体状态前5周被随机分配到认知行为压力管理（CBSM）组或仅进行评估的对照组。在血清状态通知前72小时和通知后1周，采集血样和心理测量数据。对照组受试者的抑郁情绪显著增加，但在血清阳性通知前后，丝裂原反应性和淋巴细胞计数仅略有下降。血清阳性的CBSM组受试者在抑郁方面未显示出显著的前后变化，但辅助诱导（CD4）和自然杀伤（CD56）细胞计数显著增加，对植物血凝素（PHA）的增殖反应也略有增加。个体差异分析表明，CBSM操作的心理缓冲和免疫调节作用可能部分归因于所学和所练习的放松技巧，或归因于遵守干预指南的总体意愿。
