Chatgilialoglu Chryssostomos, Ferreri Carla, Lykakis Ioannis N, Wardman Peter
ISOF, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy.
Bioorg Med Chem. 2006 Sep 15;14(18):6144-8. doi: 10.1016/j.bmc.2006.05.052. Epub 2006 Jun 12.
Free radical-catalysed cis-trans isomerization of unsaturated lipids in biomimetic models and their significance in eukaryotic cells have been explored in the last few years, an integrating hypothesis being that trans-fatty acids have their origins in both dietary sources and from isomerization of natural isomers by an endogenous radical stress. In this perspective, a summary of the achievements and a discussion of the possible biological sources of isomerizing radical species are given, indicating a need for further research on thiyl radical generation in biological systems. In this context, crucial questions remain to be answered by free radical research involving membrane lipids, thus contributing to lipidomics and embracing biology and medicine.
在过去几年中，人们对仿生模型中不饱和脂质的自由基催化顺反异构化及其在真核细胞中的意义进行了探索，一个综合的假说是反式脂肪酸既来源于饮食，也来源于内源性自由基应激导致的天然异构体的异构化。从这个角度出发，本文总结了相关研究成果，并讨论了异构化自由基物种可能的生物学来源，指出有必要对生物系统中硫自由基的产生进行进一步研究。在这种背景下，涉及膜脂的自由基研究仍有一些关键问题有待解答，这将有助于脂质组学的发展，并涵盖生物学和医学领域。
