Arce Estibaliz, Leland David S, Miller Daniel A, Simmons Alan N, Winternheimer Kelly C, Paulus Martin P
Laboratory of Biological Dynamics and Theoretical Medicine, University of California San Diego, CA 92093-0985, USA.
Neuroimage. 2006 Aug 15;32(2):704-13. doi: 10.1016/j.neuroimage.2006.04.189.
The primary purpose of this investigation was to assess the neural correlates of implicit cueing during an inhibitory task in schizophrenia when performance accuracy was matched with healthy comparison subjects.
We compared 17 individuals with chronic schizophrenia (SZ; medicated, 13.9 average years of illness) and 17 healthy comparison subjects (HC) matched for hit and false alarm rates, age, and education on a visual Go/Nogo task during functional magnetic resonance imaging. In this task, one of the go stimuli also served implicitly as a cue predictive of a subsequent inhibitory (Nogo) trial.
Findings suggest that even when matched for overall performance accuracy, individuals with SZ exhibit difficulties with inhibition and cue processing that may relate to core deficits in cognitive control and stimulus processing. In particular, these findings point towards an important role of the parietal cortex for cued inhibitory processes in healthy populations.
本研究的主要目的是在精神分裂症患者执行抑制任务且表现准确性与健康对照受试者相匹配时，评估内隐线索提示的神经关联。
我们在功能磁共振成像期间，对17名慢性精神分裂症患者（SZ；正在服药，平均病程13.9年）和17名在命中率、误报率、年龄和教育程度方面相匹配的健康对照受试者（HC）进行了视觉Go/NoGo任务比较。在该任务中，一个“执行”刺激也作为预测随后抑制（“不执行”）试验的内隐线索。
研究结果表明，即使在整体表现准确性相匹配的情况下，精神分裂症患者在抑制和线索处理方面仍存在困难，这可能与认知控制和刺激处理的核心缺陷有关。特别是，这些发现表明顶叶皮质在健康人群的线索提示抑制过程中起着重要作用。
