Smith R, Russell R G, Woods C G
J Bone Joint Surg Br. 1976 Feb;58(1):48-57. doi: 10.1302/0301-620X.58B1.818090.
The clinical features of eight patients with myositis ossificans progressiva are described and the effects of treatment with the diphosphonate EHDP, together with surgical removal of ectopic bone, are assessed. Early correct diagnosis remains unusual, mainly because the significance of the short great toes is unrecognised, and because myositis may be mistaken for bruising, sarcoma or mumps. The diphosphonate disodium etidronate (EDHP) was given to all patients in an attempt to suppress calcification of new lesions; in five of them ectopic bone was removed during the treatment. EHDP sometimes delayed the mineralisation of newly formed bone matrix after surgical removal but this delay could not be predicted. The variable effect of EHDP may depend particularly on the amount absorbed and on the activity of new bone formation.
本文描述了8例进行性骨化性肌炎患者的临床特征，并评估了双膦酸盐EHDP治疗以及手术切除异位骨的效果。早期正确诊断仍然不常见，主要是因为短拇趾的意义未被认识到，并且因为肌炎可能被误诊为瘀伤、肉瘤或腮腺炎。所有患者均给予双膦酸二钠依替膦酸盐（EDHP），试图抑制新病变的钙化；其中5例在治疗期间进行了异位骨切除。EHDP有时会延迟手术切除后新形成骨基质的矿化，但这种延迟无法预测。EHDP的效果差异可能特别取决于吸收量和新骨形成的活性。
