Stannard James P, Robinson James T, Anderson E Ratcliffe, McGwin Gerald, Volgas David A, Alonso Jorge E
Department of Surgery, Orthopaedic Division, University of Alabama at Birmingham, Birmingham, Alabama 35294-3295, USA.
J Trauma. 2006 Jun;60(6):1301-6. doi: 10.1097/01.ta.0000195996.73186.2e.
To evaluate the use of negative pressure wound therapy (NPWT) to augment healing of surgical incisions and hematomas after high-energy trauma.
This study is a prospective randomized evaluation of NPWT in trauma patients, randomizing patients with draining hematomas to either a pressure dressing (group A) or a VAC (group B). Additionally, patients with calcaneus, pilon, and high-energy tibial plateau fractures were randomized to either a standard postoperative dressing or a VAC over the sutures.
There were 44 patients randomized into the hematoma study. Group A drained a mean of 3.1 days, compared with only 1.6 days for group B. This difference was significant (p=0.03). The infection rate for group A was 16%, compared with 8% in group B. An additional 44 patients have been randomized into the fracture study. Again, a significant difference (p=0.02) was present when comparing drainage in group A (4.8 days) and group B (1.8 days). No significant difference was present at current enrollment for infection or wound breakdown.
NPWT has been used on many complex traumatic wounds. Potential mechanisms of action include angiogenesis, increased blood flow, and decreased interstitial fluid. This ongoing randomized study has demonstrated decreased drainage and improved wound healing following both hematomas and severe fractures.
评估负压伤口治疗(NPWT)对高能创伤后手术切口和血肿愈合的促进作用。
本研究是对创伤患者使用NPWT的前瞻性随机评估,将有引流血肿的患者随机分为压力敷料组(A组)或VAC组(B组)。此外,跟骨、pilon和高能胫骨平台骨折患者被随机分为标准术后敷料组或缝线处使用VAC组。
44例患者被随机纳入血肿研究。A组平均引流3.1天,而B组仅为1.6天。差异有统计学意义(p = 0.03)。A组感染率为16%,B组为8%。另有44例患者被随机纳入骨折研究。同样,比较A组(4.8天)和B组(1.8天)的引流情况时,差异有统计学意义(p = 0.02)。目前入组时,感染或伤口裂开方面无显著差异。
NPWT已用于许多复杂创伤伤口。潜在作用机制包括血管生成、血流增加和间质液减少。这项正在进行的随机研究表明,血肿和严重骨折后引流减少,伤口愈合改善。