Tachibana K, Tachibana S
Wakasugi Medical Research Institute, Fukuoka, Japan.
J Pharm Pharmacol. 1991 Apr;43(4):270-1. doi: 10.1111/j.2042-7158.1991.tb06681.x.
Ultrasonic vibration has been used to deliver insulin through the skin of hairless mice fasted overnight and partially immersed in an aqueous solution of insulin (20 units mL-1). The skin surface was exposed to ultrasonic vibration in two ultrasonic energy ranges (3000-5000 Pa and 5000-8000 Pa) at 48 kHz for 5 min. Blood glucose concentration was measured before and after exposure to insulin and ultrasonic vibration. In the group subjected to the lower energy vibrations, blood glucose fell rapidly to reach 34 +/- 11.9% of control values in 120 min, while when the animals were exposed to higher energy vibrations, the fall in blood glucose was 22.4 +/- 3.9% of control values at 120 min. The values remained low for the length of the experiment (240 min). Those exposed to insulin alone or ultrasonic vibration alone revealed no significant change in blood glucose concentration. It is postulated that ultrasonic vibration may alter skin permeability resulting in the absorption of insulin. That the blood glucose decrease was greater at the higher of the two energy ranges, suggests this factor could control insulin delivery.
超声振动已被用于通过过夜禁食并部分浸入胰岛素水溶液（20单位/毫升）的无毛小鼠皮肤来递送胰岛素。皮肤表面在48千赫的两个超声能量范围（3000 - 5000帕和5000 - 8000帕）下暴露于超声振动5分钟。在暴露于胰岛素和超声振动之前和之后测量血糖浓度。在接受较低能量振动的组中,血糖在120分钟内迅速下降至对照值的34±11.9%,而当动物暴露于较高能量振动时,在120分钟时血糖下降为对照值的22.4±3.9%。在实验持续时间（240分钟）内这些值保持较低。单独暴露于胰岛素或单独暴露于超声振动的那些小鼠血糖浓度没有显著变化。据推测,超声振动可能改变皮肤通透性从而导致胰岛素的吸收。在两个能量范围中较高能量下血糖降低更大,这表明该因素可以控制胰岛素递送。
