Wu Jianlei, Zhao Liang, Dubrunfaut Evan H, Lallo Valerie A, Chen Siyu, Wu Qianhong, Li Bo, Bracaglia Laura G
Department of Chemical and Biological Engineering, Villanova University, Villanova, Pennsylvania 19085, United States.
Hybrid Nano-Architectures and Advanced Manufacturing Laboratory, Department of Mechanical Engineering, Villanova University, Villanova, Pennsylvania 19085, United States.
Nano Lett. 2025 Jun 11;25(23):9270-9276. doi: 10.1021/acs.nanolett.5c01438. Epub 2025 May 23.
Polymeric nanoparticles (NPs) are promising tools for transporting and localizing therapeutics with intravenous delivery. Targeting these vehicles to specific tissue sites is challenging. Here, we investigate the use of low-frequency acoustic fields to drive polymeric NPs from circulating blood onto blood vessel walls by using concepts of elastic material deformation. By varying the shear flow rate and duration of acoustic field exposure, we achieved a 1000-fold increase in NP fluorescence intensity on vascular tissue compared with no acoustic field at a flow rate of 2 m/min. Interestingly, we found that acoustic-field-enhanced NP deposition is independent of NP surface chemistry. We also showcase a 100-fold increase in the area of fluorescence detected following NP delivery to an intact, human vessel wall when a localized acoustic field is applied. This work suggests that local administration of acoustic fields can control polymeric NP biodistribution after intravenous delivery and enhance the treatment of tissue-specific pathologies.
聚合物纳米颗粒（NPs）是通过静脉给药运输和定位治疗药物的有前景的工具。将这些载体靶向特定组织部位具有挑战性。在此，我们利用弹性材料变形的概念，研究使用低频声场将聚合物纳米颗粒从循环血液驱动到血管壁上。通过改变剪切流速和声场暴露持续时间，在流速为2米/分钟时，与无声场相比，我们实现了血管组织上纳米颗粒荧光强度增加1000倍。有趣的是，我们发现声场增强的纳米颗粒沉积与纳米颗粒表面化学性质无关。当施加局部声场时，我们还展示了将纳米颗粒递送至完整人体血管壁后检测到的荧光面积增加100倍。这项工作表明，局部施加声场可以控制静脉给药后聚合物纳米颗粒的生物分布，并增强对组织特异性病变的治疗。
