人参皂苷 -Rb2 对大鼠肝组织腺嘌呤核苷酸含量的影响。

Effects of ginsenoside-Rb2 on adenine nucleotide content of rat hepatic tissue.

作者信息

Yokozawa T, Fujitsuka N, Yasui T, Oura H

机构信息

Department of Applied Biochemistry, Toyama Medical and Pharmaceutical, Japan.

出版信息

J Pharm Pharmacol. 1991 Apr;43(4):290-1. doi: 10.1111/j.2042-7158.1991.tb06689.x.

DOI:10.1111/j.2042-7158.1991.tb06689.x

PMID:1676747

Abstract

In comparison with non-diabetic rats, the tissue ATP content of diabetic rats is lower and the AMP content higher. However, daily intraperitoneal administration of ginsenoside-Rb2 for several days resulted in an increase of tissue ATP content and a decrease of AMP content, characterized by an increase in the adenine nucleotide content, as well as improvement of energy charge. Thus, ginsenoside-Rb2 administration caused a change in the pattern of metabolism, activating the ATP supply system.

摘要

与非糖尿病大鼠相比，糖尿病大鼠的组织ATP含量较低，AMP含量较高。然而，连续数天每日腹腔注射人参皂苷-Rb2导致组织ATP含量增加，AMP含量降低，其特征为腺嘌呤核苷酸含量增加以及能荷改善。因此，给予人参皂苷-Rb2引起了代谢模式的改变，激活了ATP供应系统。