Elkayam O, Zinger H, Zisman E, Segal R, Yaron M, Brautbar C, Mozes E
Department of Chemical Immunology, Weizmann Institute, Rehovot, Israel.
J Rheumatol. 1991 Apr;18(4):516-21.
Fifty-one patients with rheumatoid arthritis (RA) were examined for their immune response potential to human collagen type II and III. It was found that T cells of 57% of patients with RA proliferated to collagen type III whereas only 27% of T cells of patients with osteoarthritis (OA) and healthy controls responded to this antigen by proliferation (p less than 0.04). A lower percentage (38%) of patients with RA had proliferative responses to collagen type II in comparison to 17% of responders in healthy controls. The capability to produce T cell helper factors specific to collagen type III was found to be significantly higher in patients treated with nonsteroidal antiinflammatory drugs (NSAID) (60%) in comparison to patients with OA (16%) and healthy controls (13%). Immunoregulatory drugs affected the specific T helper function in response to collagen type III but did not change the proliferative responses to collagen type II and III in patients with RA. HLA analyses revealed a significant difference in the frequency of HLA-DRw10 between our sample of patients with RA and healthy controls.
对51例类风湿关节炎（RA）患者进行了针对人Ⅱ型和Ⅲ型胶原蛋白的免疫反应潜能检测。发现57%的RA患者的T细胞对Ⅲ型胶原蛋白发生增殖反应，而骨关节炎（OA）患者和健康对照中只有27%的T细胞对该抗原发生增殖反应（P<0.04）。与健康对照中17%的反应者相比，RA患者中对Ⅱ型胶原蛋白发生增殖反应的比例较低（38%）。与OA患者（16%）和健康对照（13%）相比，使用非甾体抗炎药（NSAID）治疗的患者中产生Ⅲ型胶原蛋白特异性T细胞辅助因子的能力显著更高（60%）。免疫调节药物影响了RA患者对Ⅲ型胶原蛋白反应的特异性T辅助功能，但未改变其对Ⅱ型和Ⅲ型胶原蛋白的增殖反应。HLA分析显示，我们的RA患者样本与健康对照之间HLA-DRw10的频率存在显著差异。
