吸烟、饮酒、睡眠习惯及其他生活方式因素与日本女性系统性红斑狼疮风险：KYSS研究结果
Smoking, drinking, sleeping habits, and other lifestyle factors and the risk of systemic lupus erythematosus in Japanese females: findings from the KYSS study.
作者信息
Washio Masakazu, Horiuchi Takahiko, Kiyohara Chikako, Kodama Hiroko, Tada Yoshifumi, Asami Toyoko, Takahashi Hiroki, Kobashi Gen, Abe Takashi, Tanaka Hisato, Nogami Norihiko, Harada Mine, Tsukamoto Hiroshi, Ide Saburo, Nagasawa Kohei, Ushiyama Osamu, Hotokebuchi Takao, Okamoto Kazushi, Sakamoto Naomasa, Sasaki Satoshi, Miyake Yoshihiro, Yokoyama Tetsuji, Mori Mitsuru, Oura Asae, Sinomura Yasuhisa, Suzuki Hiromu, Yamamoto Motohisa, Inaba Yutaka, Nagai Masaki
机构信息
Sapporo Medical University School of Medicine, Sapporo, Japan.
出版信息
Mod Rheumatol. 2006;16(3):143-50. doi: 10.1007/s10165-006-0474-6.
Many risk factors have been proposed for systemic lupus erythematosus (SLE). However, there is little information about the relationship between lifestyles and SLE in Japan. Two case control studies were conducted in Kyushu, southern Japan, and in Hokkaido, northern Japan, to examine the relationship between lifestyles and development of SLE in females. The participants were 78 patients and 329 controls in Kyushu and 35 patients and 188 controls in Hokkaido. Smoking was associated with an increased risk of SLE after adjusting for age in both regions. However, in Hokkaido, this association between smoking and SLE did not reach statistical significance after adjusting for alcohol drinking. The present study suggests that smoking may increase the risk of SLE among Japanese females.
系统性红斑狼疮（SLE）已被提出许多风险因素。然而，在日本，关于生活方式与SLE之间关系的信息很少。在日本南部的九州和日本北部的北海道进行了两项病例对照研究，以探讨女性生活方式与SLE发病之间的关系。九州的参与者为78例患者和329名对照，北海道为35例患者和188名对照。在两个地区，调整年龄后，吸烟与SLE风险增加相关。然而，在北海道，调整饮酒因素后，吸烟与SLE之间的这种关联未达到统计学显著性。本研究表明，吸烟可能会增加日本女性患SLE的风险。
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