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吸烟史、饮酒与系统性红斑狼疮:一项病例对照研究。

Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study.

作者信息

Hardy C J, Palmer B P, Muir K R, Sutton A J, Powell R J

机构信息

School of Nursing, Education Centre, County Hospital, Lincoln.

出版信息

Ann Rheum Dis. 1998 Aug;57(8):451-5. doi: 10.1136/ard.57.8.451.

Abstract

OBJECTIVE

To investigate the effect of smoking on the development of systemic lupus erythematosus (SLE), and the association between alcohol consumption and the disease.

METHODS

450 subjects (150 SLE patients and 300 controls) from Nottingham, UK were interviewed in a case-control study. Controls were matched to cases for age and sex. All patients met at least four of the American Rheumatology Association criteria for SLE. Controls were randomly selected from the Nottingham Family Health Services Authority register. Information was collected by interview administered questionnaire concerning demographic variables, smoking histories, and drinking habits.

RESULTS

Analysis of the data by conditional logistic regression revealed current smokers to have a significantly increased risk of development of SLE compared with never smokers (odds ratio (OR) 1.95, 95% confidence intervals (CI) 1.14, 3.31), although ex-smokers were not at increased risk. There was also suggestion of a marked, highly significant negative association between SLE and alcohol consumption, the magnitude of which increased with units consumed.

CONCLUSIONS

This study suggests that current smokers are at increased risk of developing SLE compared with non-smokers and ex-smokers. In contrast, alcohol consumption seems to be negatively associated with the disease.

摘要

目的

研究吸烟对系统性红斑狼疮(SLE)发病的影响,以及饮酒与该疾病之间的关联。

方法

在一项病例对照研究中,对来自英国诺丁汉的450名受试者(150名SLE患者和300名对照)进行了访谈。对照在年龄和性别上与病例相匹配。所有患者至少符合美国风湿病学会SLE标准中的四项。对照从诺丁汉家庭健康服务管理局登记册中随机选取。通过问卷调查收集有关人口统计学变量、吸烟史和饮酒习惯的信息。

结果

通过条件逻辑回归分析数据发现,与从不吸烟者相比,当前吸烟者患SLE的风险显著增加(优势比(OR)为1.95,95%置信区间(CI)为1.14,3.31),尽管已戒烟者风险未增加。同时也提示SLE与饮酒之间存在显著的、高度显著的负相关,且这种相关性随饮酒量增加而增强。

结论

本研究表明,与非吸烟者和已戒烟者相比,当前吸烟者患SLE的风险增加。相比之下,饮酒似乎与该疾病呈负相关。

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The effects of alcohol on the heart: detrimental or beneficial?酒精对心脏的影响:有害还是有益?
Postgrad Med. 1997 Feb;101(2):165-8, 171-2, 175-6. doi: 10.3810/pgm.1997.02.163.
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Drugs recently associated with lupus syndromes.近期与狼疮综合征相关的药物。
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