Zhang Wei-qiang, Lin Hua, Zhou Yong-an, Wang Yun-jie, Cheng Qing-shu
Department of Thoracic Surgery, Beijing Army General Hospital, Beijing, 100700 PR China.
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2006 Jun;23(3):313-5.
Matrix metalloproteinase 1 (MMP1) plays an important role in the development of lung cancer. This study was to investigate the relation to associate the single nucleotide polymorphism(SNP)in MMP1 gene with the susceptibility to lung cancer in Northwestern Chinese population of Han nationality.
By using the methods of polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP), MMP1 -1607(1G>2G) polymorphisms in 150 patients with lung cancer, and 200 healthy controls were detected to evaluate the relationship between different genotypes and susceptibility of lung cancer.
Individuals with 2G/2G genotype had 1.77 fold risk suffering from lung cancer, when compared with ones with 1G/2G and 1G/1G genotypes. Smokers with 2G/2G genotype exhibited 3.20 fold elevated risk for lung cancer (OR 3.20; 95% CI 1.50-6.82).
The -1607(1G>2G) in promoter region of MMP1 is associated with susceptibility to lung cancer in Northwestern Chinese population of Han nationality. The genotype 2G/2G enhances the susceptibility to lung cancer.
基质金属蛋白酶1（MMP1）在肺癌发生发展中起重要作用。本研究旨在探讨MMP1基因单核苷酸多态性（SNP）与中国西北汉族人群肺癌易感性的关系。
采用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）方法，检测150例肺癌患者和200例健康对照者的MMP1 -1607（1G>2G）多态性，以评估不同基因型与肺癌易感性的关系。
与1G/2G和1G/1G基因型个体相比，2G/2G基因型个体患肺癌的风险高1.77倍。2G/2G基因型吸烟者患肺癌的风险升高3.20倍（OR 3.20；95%CI 1.50-6.82）。
MMP1启动子区-1607（1G>2G）与中国西北汉族人群肺癌易感性相关。2G/2G基因型增加了肺癌易感性。
