Hamid Saeed, Yakoob Javed, Jafri Wasim, Islam Shanul, Abid Shahab, Islam Muhammad
Section of Gastroenterology, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan.
J Pak Med Assoc. 2006 May;56(5):218-22.
To determine the frequency of peptic ulcer disease in patients on nonsteroidal anti-inflammatory drugs (NSAID).
Record of eight hundred and twenty consecutive patients undergoing upper gastrointestinal (GI) endoscopy; from January 1998 to December 2000 were reviewed. The endoscopic diagnosis varied from gastritis, peptic ulcer to duodenitis. The use of NSAID was documented by reviewing medical records of patients with peptic ulcer.
Peptic ulcers were found in 43% (353/820) patients. NSAID associated peptic ulcers were identified in 14.7% (52/353) patients. Diclofenac and aspirin were most common NSAIDs associated with peptic ulcers in 32.7% (17/52) and 30.7% (16/52) patients, respectively. Duodenal ulcer was more common than gastric ulcer 65.3% (34/52) and 42.3% (22/52), respectively. H. pylori infection was present in 46% (24/52) of the cases. NSAIDs treatment and / or H. pylori infection compared to non NSAIDs and non H. pylori infected peptic ulcer disease were significantly associated with gastric ulcer (p = 0.004) and duodenal ulcer (p = 0.009) respectively.
NSAID-associated peptic ulcer disease is common in Pakistan and most frequently associated with gastric and duodenal ulcer. H. pylori infection is common in association with NSAID related peptic ulcers.
确定使用非甾体抗炎药（NSAID）患者中消化性溃疡疾病的发生率。
回顾了1998年1月至2000年12月连续820例接受上消化道（GI）内镜检查患者的记录。内镜诊断包括胃炎、消化性溃疡和十二指肠炎。通过查阅消化性溃疡患者的病历记录来记录NSAID的使用情况。
43%（353/820）的患者发现有消化性溃疡。14.7%（52/353）的患者被确定为NSAID相关性消化性溃疡。双氯芬酸和阿司匹林是与消化性溃疡相关的最常见NSAID，分别在32.7%（17/52）和30.7%（16/52）的患者中出现。十二指肠溃疡比胃溃疡更常见，分别为65.3%（34/52）和42.3%（22/52）。46%（24/52）的病例存在幽门螺杆菌感染。与非NSAID和非幽门螺杆菌感染的消化性溃疡疾病相比，NSAIDs治疗和/或幽门螺杆菌感染分别与胃溃疡（p = 0.004）和十二指肠溃疡（p = 0.009）显著相关。
NSAID相关性消化性溃疡疾病在巴基斯坦很常见，最常与胃溃疡和十二指肠溃疡相关。幽门螺杆菌感染与NSAID相关的消化性溃疡常见并存。
