Hokland Steffen L, Pedersen Michael, Salomir Rares, Quesson Bruno, Stødkilde-Jørgensen Hans, Moonen Chrit T W
MR-Research Centre, Institute of Clinical Medicine, Aarhus University Hospital, Skejby, Denmark.
IEEE Trans Med Imaging. 2006 Jun;25(6):723-31. doi: 10.1109/tmi.2006.873296.
Focused ultrasound is very well suited for inducing noninvasive local hyperthermia. Since magnetic resonance imaging (MRI) may be employed to obtain real-time temperature maps noninvasively the combination of these two technologies offers great advantages specifically aimed toward oncological studies. Real-time identification of the target region and accurate control of the temperature evolution during the treatment has now become possible. Thermal ablation of pathological tissue, local drug delivery using thermosensitive micro-carriers and controlled transgene expression using thermosensitive promoters have recently been demonstrated with this unique technology. Based on these experiments combined focused ultrasound and MRI thermometry holds promise for future oncological diagnostics and treatment. In this paper, we review some of the recent methodological developments as well as experimental and first clinical studies using this approach.
聚焦超声非常适合诱导非侵入性局部热疗。由于可以采用磁共振成像（MRI）来无创地获取实时温度图，这两种技术的结合为肿瘤学研究带来了巨大优势。现在已经能够在治疗过程中实时识别目标区域并精确控制温度变化。最近，利用这项独特技术已证实了对病理组织进行热消融、使用热敏微载体进行局部药物递送以及使用热敏启动子进行可控转基因表达。基于这些实验，联合聚焦超声和MRI温度测量法在未来肿瘤诊断和治疗方面具有广阔前景。在本文中，我们回顾了一些近期的方法学进展以及使用该方法的实验和首次临床研究。
