Salomir Rares, Hokland Steffen, Pedersen Michael
University of Bordeaux 2, French National Institute for Health and Medical Research U 386 (INSERM).
Ugeskr Laeger. 2005 Sep 26;167(39):3667-72.
Focussed ultrasound is the only known technology that allows non-invasive local hyperthermia. Since MRI may be employed to obtain real-time temperature maps non-invasively, the combination of these two technologies offers great advantages, specifically aimed towards oncological studies. Real-time identification of the target region and accurate control of the temperature evolution during the treatment are now possible. Thermal ablation of pathological tissue, local drug delivery using thermosensitive microcarriers and controlled transgene expression using thermosensitive promoters have recently been demonstrated with this unique technology, and based on these experiments the combination of focussed ultrasound and MRI thermometry holds promise for future oncological diagnostics and treatment. In this paper we review some of the recent methodological developments as well as experimental and first clinical studies using this approach.
聚焦超声是唯一已知的能够实现非侵入性局部热疗的技术。由于磁共振成像（MRI）可用于非侵入性地获取实时温度图，这两种技术的结合具有很大优势，尤其适用于肿瘤学研究。现在能够实时识别靶区并在治疗过程中精确控制温度变化。最近，利用这项独特技术已证实可对病理组织进行热消融、使用热敏微载体进行局部药物递送以及利用热敏启动子实现可控转基因表达。基于这些实验，聚焦超声与MRI温度测量技术的结合在未来肿瘤诊断和治疗方面具有广阔前景。在本文中，我们将回顾一些近期使用该方法的方法学进展以及实验和首次临床研究。
