用于栓塞的原位可注射物理和化学凝胶化的基于NIPAAm的共聚物体系。

In-situ injectable physically and chemically gelling NIPAAm-based copolymer system for embolization.

作者信息

Lee Bae Hoon, West Bianca, McLemore Ryan, Pauken Christine, Vernon Brent L

机构信息

The Harrington Department of Bioengineering, Arizona State University, Tempe, Arizona 85287-9709, USA.

出版信息

Biomacromolecules. 2006 Jun;7(6):2059-64. doi: 10.1021/bm060211h.

The goal of this work is to make an injectable physically and chemically cross-linking NIPAAm-based copolymer system for endovascular embolization. A copolymer with N-isopropylacrylamide (NIPAAm) and hydroxyethyl methacrylate (HEMA) was synthesized and converted to poly(NIPAAm-co-HEMA-acrylate) functionalized with olefins. When poly(NIPAAm-co-HEMA-acrylate) was mixed with pentaerythritol tetrakis 3-mercaptopropionate (QT) stoichiometrically in a 0.1 N PBS solution of pH 7.4, it formed a temperature-sensitive hydrogel with low swelling through the Michael-type addition reaction and showed improved elastic properties at low frequency compared to physical gelation. This material could be useful for applications requiring water-soluble injection but lower swelling and lower creep properties than available with other soluble in-situ-gelling materials.

这项工作的目标是制备一种用于血管内栓塞的可注射的物理和化学交联的基于NIPAAm的共聚物体系。合成了一种含有N-异丙基丙烯酰胺（NIPAAm）和甲基丙烯酸羟乙酯（HEMA）的共聚物，并将其转化为用烯烃官能化的聚（NIPAAm-co-HEMA-丙烯酸酯）。当聚（NIPAAm-co-HEMA-丙烯酸酯）与季戊四醇四（3-巯基丙酸酯）（QT）在pH 7.4的0.1 N PBS溶液中按化学计量混合时，通过迈克尔型加成反应形成了具有低溶胀性的温度敏感水凝胶，并且与物理凝胶化相比，在低频下显示出改善的弹性性能。这种材料可用于需要水溶性注射但溶胀性比其他可溶性原位凝胶材料低且蠕变性能更低的应用。