从胚胎干细胞中进行神经亚型的特异性分化。
Neural subtype specification from embryonic stem cells.
作者信息
Zhang Su-Chun
机构信息
Department of Anatomy, School of Medicine and Public Health, Waisman Center, Wisconsin Stem Cell Research Program, WiCell Institute, University of Wisconsin, Madison, WI 53705, USA.
出版信息
Brain Pathol. 2006 Apr;16(2):132-42. doi: 10.1111/j.1750-3639.2006.00008.x.
Abstract
One of the keys to using embryonic stem cells (ESCs) in brain research and potential application in neurological diseases is directed differentiation of neuronal and glial subtypes. This may be achieved by application of developmental principles in guiding cell lineage specification from naïve stem cells. Establishment of defined ESC differentiation models that recapitulate in vivo development, especially from human ESCs, will most likely provide a dynamic tool for dissecting molecular mechanisms underlying early embryonic development that is otherwise not readily obtainable. This is also a rational and realistic way of producing enriched populations of functional neurons and glia for pathological analyses as well as possible therapeutic applications.
摘要
在脑研究中使用胚胎干细胞（ESC）以及将其潜在应用于神经疾病的关键之一，是神经元和神经胶质亚型的定向分化。这可以通过应用发育原理来指导从原始干细胞进行细胞谱系特化来实现。建立能够重现体内发育过程的特定ESC分化模型，尤其是从人类ESC建立模型，很可能会提供一个动态工具，用于剖析早期胚胎发育潜在的分子机制，而这些机制在其他情况下难以获得。这也是一种合理且现实的方法，可产生富集的功能性神经元和神经胶质细胞群体，用于病理分析以及可能的治疗应用。
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