年龄对胃癌患者预后的影响。

Effect of age on prognosis in patients with gastric cancer.

作者信息

Saito Hiroaki, Osaki Tomohiro, Murakami Daiki, Sakamoto Teruhisa, Kanaji Shingo, Tatebe Shigeru, Tsujitani Shunichi, Ikeguchi Masahide

机构信息

Department of Surgery, Division of Surgical Oncology, Tottori University School of Medicine, Yonago, Japan.

出版信息

ANZ J Surg. 2006 Jun;76(6):458-61. doi: 10.1111/j.1445-2197.2006.03756.x.

DOI:10.1111/j.1445-2197.2006.03756.x

PMID:16768768

Abstract

BACKGROUND

The incidence of gastric cancer among the elderly has recently been increasing; however, the prognostic value of age in patients with gastric cancer remains elusive.

METHODS

A total of 1473 patients with gastric cancer, who had undergone curative gastrectomy were reviewed to investigate the prognostic significance of age.

RESULTS

Blood vessel invasion and differentiated type were more frequently observed in elderly than nonelderly patients (P < 0.0001) and elderly patients underwent limited lymph node dissection compared with nonelderly patients (P < 0.001). Moreover, chemotherapy was carried out in nonelderly patients more frequently than in elderly patients (P < 0.005). Ten-year survival rates were 70.2 and 81.4% in elderly and nonelderly patients, respectively, and the differences were statistically significant (P < 0.001). Postoperative mortality rates were 3.2 and 2.0% in elderly and nonelderly patients, respectively. Hematogenous recurrence was more frequently observed in elderly patients than nonelderly patients (P < 0.05). Multivariate analysis showed that age was an independent prognostic factor.

CONCLUSIONS

Age clinically serves as a simple predictor of survival in patients with gastric cancer and should be taken into account along with conventional clinicopathological variables such as depth of invasion and lymph node metastasis.

摘要

背景

近年来，老年胃癌的发病率呈上升趋势；然而，年龄对胃癌患者预后的影响仍不明确。

方法

回顾性分析1473例行根治性胃切除术的胃癌患者，以探讨年龄的预后意义。

结果

老年患者血管侵犯及分化型的发生率高于非老年患者（P < 0.0001），且与非老年患者相比，老年患者行有限淋巴结清扫术的比例更高（P < 0.001）。此外，非老年患者接受化疗的频率高于老年患者（P < 0.005）。老年和非老年患者的10年生存率分别为70.2%和81.4%，差异有统计学意义（P < 0.001）。老年和非老年患者的术后死亡率分别为3.2%和2.0%。老年患者血行复发的发生率高于非老年患者（P < 0.05）。多因素分析显示，年龄是独立的预后因素。