Wolk David A, Schacter Daniel L, Lygizos Melissa, Sen N Mandu, Holcomb Philip J, Daffner Kirk R, Budson Andrew E
Department of Neurology, University of Pittsburgh, Kaufmann Medical Building, PA 15213, USA.
Brain Res. 2006 Jun 22;1096(1):148-62. doi: 10.1016/j.brainres.2006.04.050.
Within the framework of the dual process model of recognition memory, prior work with event-related potentials (ERPs) has suggested that an early component, the FN400, is a correlate of familiarity while a later component, the Late Positive Complex (LPC), is a correlate of recollection. However, other work has questioned the validity of these correlations, suggesting that the FN400 effect is too short-lived to reflect an explicit memory phenomenon and that the LPC may be influenced by decision-related factors. Using a Remember/Know paradigm we addressed these issues by (1) examining the effect of study-test delay on correctly recognized items associated with familiarity ('Know' responses) and recollection ('Remember' responses) and by (2) examining FN400 and LPC modulation associated with false alarms. Supporting the relationship of the FN400 with familiarity, attenuation of this component was present for 'Know' responses relative to correct rejections after both the short (39 min) and long (24 h) delay conditions. Attenuation of the FN400 also occurred for false alarms (responses largely driven by familiarity) relative to correct rejections. Although an increased LPC amplitude was found associated with 'Remember' responses at both delays, a decreased LPC amplitude was observed with false alarms relative to correct rejections. This latter result is discussed with regard to the possibility of an overlapping posterior negativity.
在识别记忆的双加工模型框架内，先前有关事件相关电位（ERP）的研究表明，早期成分FN400与熟悉度相关，而后期成分晚期正复合体（LPC）与回忆相关。然而，其他研究对这些相关性的有效性提出了质疑，认为FN400效应持续时间过短，无法反映明确的记忆现象，且LPC可能受决策相关因素的影响。我们采用“记得/知道”范式解决了这些问题：（1）通过考察学习-测试延迟对与熟悉度相关的正确识别项目（“知道”反应）和回忆相关的正确识别项目（“记得”反应）的影响；（2）通过考察与错误警报相关的FN400和LPC调制。支持FN400与熟悉度的关系，在短延迟（39分钟）和长延迟（24小时）条件下，相对于正确拒绝，“知道”反应中该成分均出现衰减。相对于正确拒绝，错误警报（主要由熟悉度驱动的反应）中也出现了FN400的衰减。虽然在两种延迟条件下均发现与“记得”反应相关的LPC波幅增加，但相对于正确拒绝，错误警报中观察到LPC波幅降低。结合后顶叶负波重叠的可能性对后一结果进行了讨论。
