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自膨式金属支架作为左侧梗阻性结直肠癌手术过渡与急诊切除的对照研究:一项病例匹配研究

Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study.

作者信息

Ng Ka Chun, Law Wai Lun, Lee Yee Man, Choi Hok Kwok, Seto Chi Leung, Ho Judy W C

机构信息

Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong.

出版信息

J Gastrointest Surg. 2006 Jun;10(6):798-803. doi: 10.1016/j.gassur.2006.02.006.

Abstract

This study aimed to compare the outcomes of patients who suffered from obstructing left-sided colorectal cancer, treated with self-expanding metallic stent (SEMS) as a bridge to surgery, with those who underwent emergency operation. Twenty patients who had acute obstruction due to left-sided colorectal cancer underwent surgical resection after insertion of SEMS (group I) were matched to 40 patients with emergency colonic resection (group II). The two groups were compared for the incidence of primary anastomosis, stoma rate, hospital stay, duration of intensive care, postoperative morbidity, and mortality. Both groups had similar preoperative comorbidity and stage of disease, but the tumors in group I were more distally located (P < 0.001). In group I, one patient developed colon perforation and required Hartmann's operation. All the other patients underwent elective operation with primary anastomosis. In group II, primary anastomosis was performed in 29 patients (72.5%; P = 0.047). The operative mortality of group I and group II was 5% and 12.5%, respectively (P = 0.653). Significantly shorter median postoperative hospital stay and median stay in the intensive care unit (ICU) were observed in group I (9 days [range, 5-39 days] vs. 12 days [range, 8-49 days], P = 0.015 and 0 day [range, 0-17 days] vs. 0.5 day [range, 0-18 days], P = 0.022, respectively). There were no differences in hospital mortality (P = 0.653) or 30-day mortality (P = 0.653). Both groups had similar reoperation rates, surgical complications, and medical complications. When compared with emergency resection, insertion of SEMS as a bridge to surgery for obstructing left-sided colorectal cancer is associated with a higher rate of primary anastomosis as well as a better outcome in terms of hospital stay and stay in the ICU. The wider application of this treatment option for obstructing colorectal cancer warranted further studies.

摘要

本研究旨在比较接受自膨式金属支架(SEMS)作为手术桥梁治疗的左侧结直肠癌梗阻患者与接受急诊手术患者的治疗结果。将20例因左侧结直肠癌急性梗阻在插入SEMS后接受手术切除的患者(I组)与40例接受急诊结肠切除术的患者(II组)进行匹配。比较两组的一期吻合发生率、造口率、住院时间、重症监护时间、术后发病率和死亡率。两组术前合并症和疾病分期相似,但I组肿瘤位置更靠远端(P<0.001)。I组中有1例患者发生结肠穿孔,需要行哈特曼手术。所有其他患者均接受了一期吻合的择期手术。II组中,29例患者(72.5%)进行了一期吻合(P=0.047)。I组和II组的手术死亡率分别为5%和12.5%(P=0.653)。I组术后中位住院时间和重症监护病房(ICU)中位住院时间明显更短(分别为9天[范围5 - 39天] vs. 12天[范围8 - 49天],P = 0.015;0天[范围0 - 17天] vs. 0.5天[范围0 - 18天],P = 0.022)。医院死亡率(P = 0.653)或30天死亡率(P = 0.653)无差异。两组的再次手术率、手术并发症和医疗并发症相似。与急诊切除术相比,插入SEMS作为左侧结直肠癌梗阻手术的桥梁,一期吻合率更高,在住院时间和ICU住院时间方面预后更好。这种治疗方法在结直肠癌梗阻中的更广泛应用值得进一步研究。

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