Nagase Takahiro, Koga Hisashi, Ohara Osamu
Department of Human Gene Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan.
Brief Funct Genomic Proteomic. 2006 Mar;5(1):4-7. doi: 10.1093/bfgp/ell005. Epub 2006 Feb 20.
The Kazusa cDNA project pioneered an extensive sequencing project of human cDNAs in their entirety and focused sequencing efforts particularly on large cDNAs encoding large proteins. More than 2000 human genes, referred to as 'KIAA' genes, were initially identified through this cDNA project. Since many KIAA genes still remain functionally uncharacterized, our current focus is to determine their biological functions in vivo. In this review, we describe the current status of the Kazusa mammalian cDNA resources and the future direction of the functional characterization of KIAA genes.
Kazusa cDNA项目率先开展了对人类cDNA进行全面测序的项目，并将测序工作特别集中在编码大蛋白的大型cDNA上。通过这个cDNA项目，最初鉴定出了2000多个被称为“KIAA”基因的人类基因。由于许多KIAA基因的功能仍未得到表征，我们目前的重点是确定它们在体内的生物学功能。在这篇综述中，我们描述了Kazusa哺乳动物cDNA资源的现状以及KIAA基因功能表征的未来方向。
