HUGO Gene Nomenclature Committee, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Nucleic Acids Res. 2019 Jan 8;47(D1):D786-D792. doi: 10.1093/nar/gky930.
The HUGO Gene Nomenclature Committee (HGNC) based at EMBL's European Bioinformatics Institute (EMBL-EBI) assigns unique symbols and names to human genes. There are over 40 000 approved gene symbols in our current database of which over 19 000 are for protein-coding genes. The Vertebrate Gene Nomenclature Committee (VGNC) was established in 2016 to assign standardized nomenclature in line with human for vertebrate species that lack their own nomenclature committees. The VGNC initially assigned nomenclature for over 15000 protein-coding genes in chimpanzee. We have extended this process to other vertebrate species, naming over 14000 protein-coding genes in cow and dog and over 13 000 in horse to date. Our HGNC website https://www.genenames.org has undergone a major design update, simplifying the homepage to provide easy access to our search tools and making the site more mobile friendly. Our gene families pages are now known as 'gene groups' and have increased in number to over 1200, with nearly half of all named genes currently assigned to at least one gene group. This article provides an overview of our online data and resources, focusing on our work over the last two years.
人类基因命名委员会（HGNC）设在欧洲生物信息学研究所（EMBL-EBI），负责为人类基因分配独特的符号和名称。我们目前的数据库中有超过 40000 个经过批准的基因符号，其中超过 19000 个是编码蛋白质的基因。脊椎动物基因命名委员会（VGNC）于 2016 年成立，旨在为缺乏自己命名委员会的脊椎动物物种分配标准化的命名法。VGNC 最初为黑猩猩中的超过 15000 个编码蛋白质的基因分配了命名法。我们已经将这个过程扩展到其他脊椎动物物种，为牛和狗命名了超过 14000 个编码蛋白质的基因，为马命名了超过 13000 个编码蛋白质的基因。我们的 HGNC 网站 https://www.genenames.org 进行了重大设计更新，简化了主页，以便更轻松地访问我们的搜索工具，并使网站更适合移动设备。我们的基因家族页面现在称为“基因组”，数量增加到 1200 多个，目前几乎一半的命名基因至少被分配到一个基因组中。本文概述了我们的在线数据和资源，重点介绍了我们在过去两年中的工作。
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