亮抑酶肽，一种由侧孢芽孢杆菌BMI156 - 14F1产生的新型氨肽酶M抑制剂。II. 亮抑酶肽的结构测定。

Leuhistin, a new inhibitor of aminopeptidase M, produced by Bacillus laterosporus BMI156-14F1. II. Structure determination of leuhistin.

作者信息

Yoshida S, Naganawa H, Aoyagi T, Takeuchi T, Takeuchi Y, Kodama Y

机构信息

Institute of Microbial Chemistry, Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1991 Jun;44(6):579-81. doi: 10.7164/antibiotics.44.579.

DOI:10.7164/antibiotics.44.579

PMID:1676998

Abstract

Leuhistin, a new inhibitor of aminopeptidase M, has been isolated from the culture broth of Bacillus laterosporus BMI156-14F1. The structure of leuhistin was determined by NMR studies. X-Ray and chemical analysis confirmed the absolute structure to be (2R,3S)-3-amino-2-hydroxy-2-(1H-imidazol-4-ylmethyl)-5-methylhe xanoic acid.

摘要

亮抑酶肽是一种新型氨肽酶M抑制剂，已从侧孢芽孢杆菌BMI156 - 14F1的培养液中分离出来。通过核磁共振研究确定了亮抑酶肽的结构。X射线和化学分析证实其绝对结构为(2R,3S)-3-氨基-2-羟基-2-(1H-咪唑-4-基甲基)-5-甲基己酸。