氨基肽酶B的新型抑制剂OF4949。II. 结构解析。

OF4949, new inhibitors of aminopeptidase B. II. Elucidation of structure.

作者信息

Sano S, Ikai K, Katayama K, Takesako K, Nakamura T, Obayashi A, Ezure Y, Enomoto H

出版信息

J Antibiot (Tokyo). 1986 Dec;39(12):1685-96. doi: 10.7164/antibiotics.39.1685.

DOI:10.7164/antibiotics.39.1685

Abstract

The structures of OF4949-I, II, III and IV were identified by analysis of the products of their chemical degradation and by 1H NMR, 13C NMR, and mass spectrometry. These compounds were new cyclic peptides containing diphenyl ether as a chromophore. OF4949-I had two amino acids, beta-hydroxy-L-asparagine and 4-methylisodityrosine. The structural differences between I and II and between III and IV lay solely in the diphenyl ether moiety; the phenolic hydroxyl group in II and IV was methylated in I and III. OF4949-III and IV contained L-asparagine instead of the beta-hydroxy-L-asparagine moiety of I and II.

摘要

通过对OF4949-I、II、III和IV化学降解产物的分析以及1H NMR、13C NMR和质谱法确定了它们的结构。这些化合物是含有二苯醚作为发色团的新型环肽。OF4949-I含有两种氨基酸，β-羟基-L-天冬酰胺和4-甲基异二酪氨酸。I与II之间以及III与IV之间的结构差异仅在于二苯醚部分；II和IV中的酚羟基在I和III中被甲基化。OF4949-III和IV含有L-天冬酰胺，而不是I和II中的β-羟基-L-天冬酰胺部分。